Search results for " Hank"
showing 10 items of 13 documents
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
Reconfigurations in sustainability transitions : a systematic and critical review
2021
Two streams of literature have become especially prominent in understanding social change toward sustainability within the past decades: the research on socio-technical transitions and applications of social practice theory. The aim of this article is to contribute to efforts to create dialogue between these two approaches. We do this by focusing on the concept of reconfiguration, which has become a much-used, but poorly defined notion in the discussion on sustainability transitions. To understand what is defined as reconfiguration in systems and practices, and how the understanding of reconfiguration in regimes could benefit from insights about reconfiguration in practices, we conducted a …
Hank Green: Ihan mieletön juttu
2019
Kirja-arvostelu teoksesta Hank Green: Ihan mieletön juttu. (An Absolutely Remarkable Thing.) Tammi 2019. Suom. Kaisa Kattelus. 388 s. nonPeerReviewed
Design of Public Procurement Auctions: Evidence from Cleaning Contracts
2018
We analyze a regime change from beauty contests to first-price sealed-bid and scoring auctions, using Swedish data on public procurement of cleaning services. In beauty contests, the lowest bid often lost, leaving substantial money on the table. The procurement costs were similar before and after the regime change: (i) Entry strongly decreases the procurement cost but did not change. Entry would have decreased had the municipalities not adjusted the objects of auctions. (ii) Municipalities favored in-house suppliers in the old regime, leading to more aggressive bidding by others. With favoritism reduced, these changes balanced each other out. Peer reviewed
"Työkokemukseen perustuvaa osaamista ei prosessissa arvostettu " : tutkimus hyväksilukujen ja aiemmin hankitun osaamisen tunnustamisen toteutumisesta…
2016
Hankintalaki - kilpailuttamisen karikot hankintayksikön näkökulmasta
2010
Tällä tutkimuksella on haluttu selvittää markkinaoikeuden vuonna 2007 voimaan astuneen hankintalain nojalla antamien ratkaisujen pohjalta ne julkisten hankintojen kilpailuttamiseen liittyvät seikat, joihin hankintayksiköiden tulisi kiinnittää erityistä huomiota kyetäkseen mahdollisimman moitteettomaan kilpailuttamisprosessiin ja välttääkseen näin mahdolliset oikeustoimet hankintojen viivästysseuraamuksineen. Kyseessä on empiirinen, pääosin kvantitatiivinen kokonaistutkimus, jonka tarkoitus on olla selittävä. Aineistona on käytetty markkinaoikeuden internet-sivustoillaan saatavilla olevia 30.9.2009 mennessä antamia yhteensä 313 ratkaisua, joista on analysoitu sekä hakemusten että niiden hyvä…
Exploring the Critical Success Factors in Social and Health Care Information Systems Project Procurement
2020
A welfare reform involving the mixing of social and health services is being introduced by the Finnish government. Several factors have been identified for this shift, the most relevant of which is that many information systems are not interoperable and data-related problems have been identified. Management and isolated offers of service. Digitalizing to solve these issues is part of the government’s policy. This paper outlines the change landscape and explores the architectural options of the proposed digitalisation process and crucial success factors. The Undertaking The design is applied to the largest county, which consists of over 1,900 information systems related to social support and…
Ketterät sopimustyypit ja hinnoittelumallit julkisissa tietojärjestelmähankinnoissa
2017
Agile contracts and pricing models in public procurements of information systems. Process of public information system procurement has been overlooked in information system science. Especially empirical study of contract types and pricing models that support agile development has been neglected. The aim of this research is to fill this research gap. The research question is how agile contracts and pricing models can be applied in public procurements of information systems. This research investigates what ways and practices for implementing agile contracts and pricing models exist in public sector. The approach of this research is qualitative. The research question will be answered by analyz…
Julkiset hankinnat ja kokonaistaloudellinen edullisuus erityisesti sosiaali- ja terveydenhuollon palveluhankintojen näkökulmasta
2008
A Dynamic Life-cycle Model for the Provisioning of Software Testing Services: Experiences from A Case Study in the Chinese ICT Sourcing Market
2011
ICT-enabled international sourcing of software-intensive systems and services (eSourcing) is a powerful strategy for managing businesses more effectively. China is becoming a superpower for eSourcing service provisioning, but most Chinese providers are small or medium-sized and leverage the mediated eSourcing model, delivering services to foreign ICT clients that interface with end-clients onshore. This model restricts the providers to low-value projects. This paper probes eSourcing of software testing services within the Chinese market. Testing is studied for two reasons. First, testing is one of the best ICT services, small- and medium-sized providers can provide to develop domain and tec…